Nearly everyone in the business world has had occasion at hundreds of time to press CTRL + ALT + DELETE in Windows in order to deal with stalled out applications and other problems. Not everyone realizes that Windows makes available an advanced version of the Task Manager named Process Explorer, which is available for download here, https://technet.microsoft.com/en-us/sysinternals/bb896653 . Process Explorer provides many more options for deleting unwanted files. It's freeware, and is put out by Sysinternals which has been acquired by Microsoft.
This task manager allows you to right click on an individual file and select 'Kill Process Tree' to deactivate the active file any any files associated with running a program.